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KMID : 0616120110420020161
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Korean Journal of Pharmacognosy
2011 Volume.42 No. 2 p.161 ~ p.168
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Screening of Herbal Medicines from China with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (VI)
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Lee Yun-Mi
Kim Young-Sook
Kim Joo-Hwan
Kim Jin-Sook
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Abstract
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Advanced glycation end products (AGEs) has been shown to play an important role in the development of the diabetic complications. The AGEs inhibitors or cross-link breakers attenuate various functional and structural manifestations of diabetic complications. In this study, 69 China herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 28 herbal medicines =<50 ) were found to have stronger AGEs inhibitory activity compared with aminoguanidine (=59.77 ). Particularly, 5 herbal medicines, Camptotheca acuminata (stem, leaf), Eurya groffii (stem, leaf), Cornus Capitata (leaf), Mucuna birdwoodiana (root), Nelumbo nucifera (fruit, seed) showed more potent inhibitory activity (approximately 6-27 fold) than the positive control aminoguanidine
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KEYWORD
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Advanced glycation endproducts (AGEs), Diabetic complications, Herbal medicines
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